Puppies can be bred during their second heat. Generally speaking, the first time a dog goes into heat is about 6-8 months, but at this time, the dog's body is not fully mature, and the puppies born are not healthy. Therefore, it is recommended to wait until the dog is in heat for the second time before breeding. The second heat is when the dog is one or one and a half years old.

What to pay attention to when breeding puppies:

1. Be sure to avoid fighting or strenuous exercise due to restlessness during breeding, and avoid stress behaviors in puppies.

2. Nutrition must keep up, and trace elements and vitamins must also be supplemented so that the dog can have a good body for breeding and raising babies.

3. Prohibited drugs: florfenicol, dexamethasone, etc. cannot be given to puppies.

4. Make sure that the dog’s mating venue is familiar with it in advance to enhance the dog’s sense of security and facilitate smooth mating.