Uremia in dogs refers to a body poisoning syndrome caused by the accumulation of metabolites and other toxic substances in the body due to renal failure in dogs. Let’s take a look at the causes of uremia!

Alaskan Malamute

Causes of canine uremia:

Uremia is a manifestation of severe renal failure in dogs, and its occurrence is related to the following factors.

1. Absorption of intestinal toxic substances, such as phenol, tyramine, phenylethylenediamine, etc., are absorbed from the intestine into the blood. Due to kidney failure and reduced liver detoxification function, the poison accumulates in the blood and causes poisoning.

2. Due to kidney failure, urea enters the intestinal cavity, is decomposed by intestinal bacteria into ammonia and ammonium salts, and is then absorbed into the blood, causing symptoms of nervous system poisoning.

3. The accumulation of toxic products from the decomposition of certain proteins, such as guanidine compounds, can inhibit the activity of certain enzymes (lactate dehydrogenase, ATPase, etc.) in the body, causing convulsions in dogs, and can also induce gastroenteritis and pericarditis in dogs. , bleeding and reduced immune function, etc.

4. Acidosis occurs due to disorder in the excretion of acidic metabolites, causing changes in respiratory and cardiovascular activities and coma.