Dogs are sterilized through surgery. There is no medicine that can sterilize dogs. It is recommended to go to a pet hospital for surgical sterilization. If you give your dog random medications, it may affect your dog's health. For male dogs, the best time for neutering is around 6 to 8 months of age. For female dogs, 4 to 5 days after the first estrus is the best time for neutering.

Benefits of neutering dogs:

1. Control the birth rate of puppies. Control the birth rate of puppies and reduce abandonment due to excessive births. Neutering dogs can effectively reduce the birth rate of dogs, control the overall number of dogs, and reduce the number of pets being abandoned and sent to shelters.

2. Improve the male dog’s random peeing behavior. Many male dogs will urinate indiscriminately when they are in estrus. If the dog is neutered, this desire of male dogs will be reduced, and the situation of indiscriminate urination will be improved.

3. Reduce the problem of male dogs running around. If the male dog is not neutered, as soon as they smell the hormonal smell emitted by the female dog during estrus, they will try their best to chase after her. If it is a large dog, the owner really cannot control the dog, and there is really nothing you can do if they run away. But neutering your dog can alleviate this condition.