The clinical treatment for osteoarthritis is mainly anti-inflammatory and analgesic; providing synthetic substrates for chondrocytes and synoviocytes; and rehabilitation exercises to promote effective rehabilitation.

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Most anti-inflammatory and analgesic drugs for osteoarthritis are non-steroidal anti-inflammatory drugs, and the main functions of drugs to improve the condition of osteoarthritis are: Provides synthetic substrates for chondrocytes and synovial cells, inhibits the activity of degrading enzymes and inflammatory substances in the cartilage matrix and synovial fluid, and inhibits the embolization of synovium and subchondral intraosseous blood vessels. Common chondroprotective agents include glucosamine hydrochloride and sulfate. Chondroitin, unsaturated fatty acids, green-lipped fetus, hyaluronic acid, etc. Low-dose doxycycline acts as a protease inhibitor to degrade enzymes in joint fluid.