Reasons why dog ​​vaccines fail. You need to understand these reasons!

Aug 30,2024
5Min

The problem of maternal antibodies

Newborn puppies or kittens are born from the placenta or colostrum. The mother acquires antibodies and is protected.
When should I start vaccination? This is related to maternal antibody levels. The time that maternal antibodies circulate in the body is different in different individuals and different antibodies.
Every individual has a susceptible period, which varies in length, from days to weeks. During this period, the level of maternal antibodies is too high to prevent the vaccine from working, but too low to be effective. Fight infectious diseases. Even if you are vaccinated during this period, you can still get infectious diseases. The susceptibility periods are also different between different litters and even between different individuals in the same litter.
Research shows that against parvovirus, puppies are only 25% effective at 6 weeks of age, 40% effective at 9 weeks old, 60% effective at 16 weeks old, and 60% effective at 18 weeks old It's 95% effective.

The interval between vaccination and exposure to infectious diseases is too short

Vaccines do not immediately stimulate the body to produce antibodies as soon as they are vaccinated. It takes several days to weeks to produce effective antibodies.
For example, effective protection against coronavirus does not develop until 2-3 weeks after the second vaccine injection.
When a pet is vaccinated, it is already in the incubation period of the disease, or there is a severe parasitic infection. After vaccination, the pet will inevitably become ill,
resulting in the failure of immunity.

Different strains of viruses or bacteria

If the virus or bacterial strain mutates, vaccination will also fail. For example, when a mutant strain of parvovirus was discovered clinically, routine parvovirus vaccination failed.

Vaccine destruction

Due to improper storage or transportation , the attenuated vaccine may become inactivated and cause immune failure; if the temperature is higher than 4 degrees during the storage and transportation of the vaccine, the vaccine will be ineffective!

Improper use of vaccines

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The route of vaccination is not carried out according to the requirements of the vaccine, such as subcutaneous injection, intramuscular injection or intranasal drip. There must also be a dose of injection. Dog vaccines are all based on head dose, not weight, age, etc.
Note: What is the amount of injection per head? For example (not used as reference data): two doses of canine distemper vaccine are injected into each dog, which means that each dog is injected with 2 doses of the vaccine diluent.

Improper immunization procedure

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If the injection interval is too short, interference will occur between vaccines. If the interval is too long, the effect will be reduced. Usually, the injection interval of the two vaccines is 2-3 weeks, which is more reasonable, except of course for rabies.

Different varieties

Different breeds have different sensitivities and responses to infectious diseases. The immune program may need to be adjusted for more sensitive breeds.

Immune deficiency

If the body’s immune system is defective, it will notA normal immune response to the vaccine can also fail.

During the illness

< section>Fever can suppress the body's immune response to canine distemper virus, and infection with certain viruses can also reduce the body's immune response to vaccines. Therefore, we have always emphasized that dogs need to be vaccinated when they are healthy.
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