Dog vaccination failure may be due to genetic factors

The immune response of the animal body to vaccination is controlled to a certain extent by genetic factors. There are many breeds of dogs, and their immune responses are different. Even dogs of the same breed may have different immune responses to the same vaccine. Some dogs may even have congenital immune deficiencies, leading to immune disorders.

Dog vaccination failure or interference from maternal antibodies

This is one of the most common factors for immune disorders. A certain level of maternal antibodies can protect puppies from early infection with infectious diseases. is of extremely important significance. However, due to differences in the individual immune responses of breeding dogs and the differences in vaccines used in breeding dogs (there are also large differences in the induced maternal antibody titers), maternal antibody levels in puppies from different sources vary. If all puppies are vaccinated at the same age, puppies with too high maternal antibodies may interfere with the immune response of the vaccine, while puppies with too low maternal antibodies may be latent for infectious diseases when vaccinated. Infectious phase, leading to immune dysregulation. Even the maternal antibody titers among different individuals of puppies from the same female dog are not necessarily exactly the same. If a fixed first vaccination procedure is adopted, it will also interfere with the immune response of the vaccine and lead to immune disorders.

Dog vaccination failure may be due to nutritional factors

Antigens enter the body and produce different levels of immune responses - cellular immunity and humoral immunity, both of which require certain nutrients. Lack or insufficiency of nutrients, especially vitamins A, D, B, E and various trace elements and full-price proteins, will affect the production speed or quantity of immune antibodies, resulting in lag in immune response or immune response ability. Decrease, leading to immune disorders.