As the body temperature increased for the second time and did not drop, the condition further worsened and the fever remained high.

The spirit goes up and down. Due to loss of appetite and lack of nutrition, it will be difficult to walk, become less likely to move, and become highly depressed and lethargic. Feeding will also be particularly objectionable.

The secreted pus covers the eyes, and the eyes will stick together and cannot be opened.

Eye injuries in some dogs are clinically characterized by conjunctivitis and keratitis (keratitis is mostly seen about 15 days after onset, and the cornea turns white). In severe cases, corneal ulcers, perforations, and blindness may occur.

In the later stages of canine distemper, dogs have pus flowing from their noses, their noses are severely dry and cracked, and more pus leaks out to block their nostrils and make it difficult to breathe.

In the later stage, the corners of the mouth will be corroded.

Dry cough lasts for more than 1 month. Later, it turned into a wet cough and difficulty breathing

Nervous symptoms appear, mostly between 7 and 21 days, and some may show neurological symptoms from the beginning.

Neurosymptomatic canine distemper is a typical manifestation of canine distemper in the late stage, and most of them appear about 10 days after the above symptoms.

Because the canine distemper virus infects different parts of the central nervous system, the symptoms vary. The virus damages the brain and manifests as epilepsy, circling, abnormal standing posture, unsteady gait, ataxia, foaming at the mouth, paroxysmal twitching of masticatory muscles and limbs, continuous twitching and other neurological symptoms.

It is easy to leave sequelae. Transplacental infection in "puppies" can produce neurological symptoms between 28 and 42 days. If some dogs suffer from pyoderma in the later stages, the induration becomes soft, the skin in the center becomes thinner, and deep ulceration occurs, with pus and blood flowing out. In severe cases, large-scale ulceration may occur.

Symptoms of neurological canine distemper appear. In addition to the symptoms of canine distemper in the mid-term, affected dogs occasionally also show symptoms of neurological canine distemper, such as wilting, muscle pain and weakness, paroxysmal muscle spasms, balance disorders, circular movements, epileptic panic and coma, etc. , generally the dog will die after this symptom lasts for 1-2 weeks.