The impression left on pet owners by the Shar-Pei is that it has a short back, a big head and a small body, a black nose, a dark blue tongue, and the most memorable thing is the deep wrinkles all over its body. Usually humans develop wrinkles as they age, so why do Shar-Pei dogs have so many wrinkles? Today I will give you some popular science for pet owners.

Researchers at the Autonomous University of Barcelona have discovered that Shar-Pei dogs have mucinosis, which is caused by genetic disorders. The significance of this research is that it can help Shar-Pei dogs reproduce better and help improve their health. Mucinosis in Shar-Pei dogs is caused by the accumulation of hyaluronic acid (one of the main components of the spaces between tissue cells) in the skin structure. This cumulative effect results in very high concentrations of hyaluronic acid in their blood. After isolating Shar-Pei skin fibroblasts for culture studies, scientists confirmed that the massive synthesis of hyaluronic acid is due to an abnormal increase in activity (overexpression) of an enzyme called HAS2, which is responsible for the One of three enzymes that synthesize acids.

Hyaluronic acid mainly exists in the spaces of various tissue cells, while hyaluronic acid in Shar-Pei dogs continues to accumulate in skin tissues and blood vessels, eventually leading to the occurrence of mucinosis. Scientists' research on Shar Pei skin fibroblast tissue revealed that an enzyme called HAS2 is the "culprit".

Scientists are also conducting in-depth research on what genes cause enzyme abnormalities. In the future, the results of this scientific research will also make a huge contribution to human society. It can be seen that there are many treasures hidden in the Shar-Pei. Start raising a Shar-Pei from now on and discover the unknown of life with the editor!