If a Tibetan Mastiff is kept for less than three months, it may reacknowledge its owner after leaving its owner. An adult Tibetan Mastiff may show signs of not eating or drinking after leaving its owner, and the Tibetan Mastiff's personality will also change significantly. If they are sensitive, they may lose trust in their owners, or even attack them. Some Tibetan Mastiffs may stay at the door of their owners' homes waiting for their owners to return.

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The Tibetan Mastiff is a very loyal dog breed and will generally only end up with one owner in its life. If the owner leaves it, the Tibetan Mastiff may have problems. Some Tibetan Mastiffs will become particularly sensitive to signs of not eating or drinking, and may lose trust in their owners. When they meet their owners again, they may refuse to recognize their owners again, and may even attack their owners. After some Tibetan Mastiffs leave their owners, they may stay at the door of their owners' homes waiting for their owners to raise them again.